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Interstitium: The Undiscovered Organ in Our Body


Researchers have identified a new human organ hiding in plain sight, in a discovery they hope could help them understand the spread of cancer within the body. Layers long thought to be dense, connective tissue is actually a series of fluid-filled compartments researchers have termed the “interstitium”.

These compartments are found beneath the skin, as well as lining the gut, lungs, blood vessels and muscles, and join together to form a network supported by a mesh of strong, flexible proteins.

A new analysis published in the journal Scientific Reports is the first to identify these spaces collectively as a new organ and try to understand their function.
Remarkably, the interstitium had previously gone unnoticed despite being one of the largest organs in the human body.

The team behind the discovery suggest the compartments may act as “shock absorbers” that protect body tissues from damage.
Mount Sinai Beth Israel Medical Center medics Dr. David Carr-Locke and Dr. Petros Benias came across the ‘interstitium’ while investigating a patient’s bile duct, searching for signs of cancer. They noticed cavities that did not match any previously known human anatomy and approached New York University pathologist Dr. Neil Theise to ask for his expertise.

The researchers realized traditional methods for examining body tissues had missed the ‘interstitium’ because the “fixing” method for assembling medical microscope slides involves draining away fluid – therefore destroying the organ’s structure.

Instead of their true identity as bodywide, fluid-filled shock absorbers, the squashed cells had been considered a simple layer of connective tissue. Having arrived at this conclusion, the scientists realized this structure was found not only in the bile duct but surrounding many crucial internal organs.

Understanding this newly discovered frontier in human anatomy could allow scientists to develop new tests for cancer.
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